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Int J Psychophysiol. 2016 Jan;99:96-102. doi: 10.1016/j.ijpsycho.2015.11.008. Epub 2015 Nov 19.

Could BDNF be involved in compensatory mechanisms to maintain cognitive performance despite acute sleep deprivation? An exploratory study.

Giacobbo BL1, Corrêa MS1, Vedovelli K2, de Souza CE3, Spitza LM3, Gonçalves L3, Paludo N3, Molina RD4, da Rosa ED5, Argimon II4, Bromberg E6.

Author information

1
Neurobiology and Developmental Biology Laboratory, Faculty of Biosciences, Pontifical Catholic University of Rio Grande do Sul, Porto Alegre 90619-900, Brazil; National Institute for Translational Medicine (INCT-TM), Porto Alegre, Rio Grande do Sul 90035-003, Brazil.
2
Neurobiology and Developmental Biology Laboratory, Faculty of Biosciences, Pontifical Catholic University of Rio Grande do Sul, Porto Alegre 90619-900, Brazil; Institute of Geriatrics and Gerontology, Pontifical Catholic University of Rio Grande do Sul, Porto Alegre 90619-900, Brazil; National Institute for Translational Medicine (INCT-TM), Porto Alegre, Rio Grande do Sul 90035-003, Brazil.
3
Neurobiology and Developmental Biology Laboratory, Faculty of Biosciences, Pontifical Catholic University of Rio Grande do Sul, Porto Alegre 90619-900, Brazil.
4
Institute of Geriatrics and Gerontology, Pontifical Catholic University of Rio Grande do Sul, Porto Alegre 90619-900, Brazil.
5
Laboratory of Molecular Psychiatry, Federal University of Rio Grande do Sul, Porto Alegre 90035-003, Brazil.
6
Neurobiology and Developmental Biology Laboratory, Faculty of Biosciences, Pontifical Catholic University of Rio Grande do Sul, Porto Alegre 90619-900, Brazil; National Institute for Translational Medicine (INCT-TM), Porto Alegre, Rio Grande do Sul 90035-003, Brazil. Electronic address: bromberg@pucrs.br.

Abstract

BACKGROUND:

Neuroimaging studies suggest that acute sleep deprivation can lead to adaptations, such as compensatory recruitment of cerebral structures, to maintain cognitive performance despite sleep loss. However, the understanding of the neurochemical alterations related to these adaptations remains incomplete.

OBJECTIVE:

Investigate BDNF levels, cognitive performance and their relations in healthy subjects after acute sleep deprivation.

METHODS:

Nineteen sleep deprived (22.11±3.21years) and twenty control (25.10±4.42years) subjects completed depression, anxiety and sleep quality questionnaires. Sleep deprived group spent a full night awake performing different playful activities to keep themselves from sleeping. Attention, response inhibition capacity and working memory (prefrontal cortex-dependent) were assessed with Stroop and Digit Span tests. Declarative memory (hippocampus-dependent) was assessed with Logical Memory test. Serum BDNF was measured by sandwich ELISA. Data were analyzed with independent samples T-test, ANOVA, ANCOVA and curve estimation regressions. p<0.05 was deemed statistically significant.

RESULTS:

The sleep deprived group showed higher BDNF levels and normal performance on attention, response inhibition capacity and working memory. However, declarative memory was impaired. A sigmoidal relation between BDNF and Stroop Test scores was found.

CONCLUSIONS:

Increased BDNF could be related, at least in part, to the maintenance of normal prefrontal cognitive functions after sleep deprivation. This potential relation should be further investigated.

Copyright © 2015 Elsevier B.V. All rights reserved.

PMID:
26602839
DOI:
10.1016/j.ijpsycho.2015.11.008
[Indexed for MEDLINE]

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