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Alzheimers Dement. 2016 May;12(5):604-13. doi: 10.1016/j.jalz.2015.10.006. Epub 2015 Nov 18.

Benzodiazepine, psychotropic medication, and dementia: A population-based cohort study.

Author information

1
Inserm Research Center for Epidemiology and Biostatistics (U897) - Team Neuroepidemiology, Bordeaux, France; University of Bordeaux, Bordeaux, France.
2
Inserm Research Center for Epidemiology and Biostatistics (U897) - Team Neuroepidemiology, Bordeaux, France.
3
University of Bordeaux, Bordeaux, France; Inserm Unit 897-Epidemiology and Biostatistics Research Center (U897) - Team Epidemiology and Neuropsychology of Cerebral Aging, Bordeaux, France.
4
Inserm Unit 1061-Neuropsychiatry: Epidemiological and Clinical Research, University of Montpellier, Montpellier, France.
5
University of Bordeaux, Bordeaux, France; Inserm Unit 657-Pharmacoepidemiology and Evaluation of the Impact of Health Products on Populations, Bordeaux, France.
6
Inserm Research Center for Epidemiology and Biostatistics (U897) - Team Neuroepidemiology, Bordeaux, France; University of Bordeaux, Bordeaux, France. Electronic address: christophe.tzourio@u-bordeaux.fr.

Abstract

INTRODUCTION:

Benzodiazepine use has been associated with increased risk of dementia. However, it remains unclear whether the risk relates to short or long half-life benzodiazepines and whether it extends to other psychotropic drugs.

METHODS:

Prospective cohort study among 8240 individuals ≥65, interviewed on medication use. Incident dementia confirmed by an end point committee after a multistep procedure.

RESULTS:

During a mean of 8 years of follow-up, 830 incident dementia cases were observed. Users of benzodiazepines at baseline had a 10% increased risk of dementia (adjusted hazard ratio [HR], 1.10; 95% confidence interval, 0.90-1.34). However, long half-life (>20 hours) benzodiazepine users had a marked increased risk of dementia (HR = 1.62; 1.11-2.37) compared with short half-life users (HR = 1.05; 0.85-1.30). Users of psychotropics had an increased risk of dementia (HR = 1.47; 1.16-1.86).

DISCUSSION:

Results of this large, prospective study show increased risk of dementia for long half-life benzodiazepine and psychotropic use.

KEYWORDS:

Alzheimer's disease; Benzodiazepine; Cohort studies; Dementia; Psychotropic medication

PMID:
26602630
DOI:
10.1016/j.jalz.2015.10.006
[Indexed for MEDLINE]

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