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Nutrition. 2016 Feb;32(2):222-7. doi: 10.1016/j.nut.2015.08.010. Epub 2015 Sep 3.

Effect of bovine lactoferrin from iron-fortified formulas on diarrhea and respiratory tract infections of weaned infants in a randomized controlled trial.

Author information

1
Department of Nutrition, Chengdu Women's and Children's Central Hospital, Chengdu, China. Electronic address: surgemail@163.com.
2
Beingmate Baby & Child Food Co., Ltd, Hangzhou, China.
3
Department of Preventive Health Care, Women and Children's Health Care Hospital of Qing Baijing, Qing Baijing District, Chengdu, China.
4
Department of Child Health Care, Women and Children's Health Care Hospital of Jinniu, Jinniu District, Chengdu, China.
5
Department of Pediatrics, Women and Children's Health Care Hospital of Dayi, Dayi County, Chengdu, China.
6
Department of Child Health Care, Women and Children's Health Care Hospital of Chenghua, Chenghua District, Chengdu, China.
7
Department of Pediatrics, Women and Children's Health Care Hospital of Dongpo, Dongpo District, Meishan, China.
8
Department of Child Health Care, Women and Children's Health Care Hospital of Xindu, Xindu District, Chengdu, China.
9
Department of Internal Medicine, Rush University Medical Center, Chicago.

Abstract

OBJECTIVE:

The aim of this study was to evaluate the effect of supplementation with bovine lactoferrin (bLf) from iron-fortified formulas on diarrhea and respiratory tract infections (RTIs) in weaned infants.

METHODS:

In this prospective, multicenter, controlled intervention study, 260 infants ages 4 to 6 mo who previously were exclusively breastfed but weaned were randomized into two groups: a lactoferrin-fortified formula milk group (fortified group, FG, containing lactoferrin 38 mg/100 g milk) and a no lactoferrin-fortified milk (control group, CG); breastfed infants were enrolled and served as a reference group (breastfed group, BG). The intervention duration was 3 mo. The morbidity of diarrhea and RTIs were collected during supplementation.

RESULTS:

The results of the study demonstrated evidence of a lower incidence rate of respiratory-related illnesses and fewer symptoms of running nose, cough, and wheezing for infants in the FG and BG groups compared with those in the CG (P < 0.05). Despite the undistinguished incidence rate of vomiting, nausea, and colic, the occurrences of diarrhea-related illnesses were significantly lower for children in the FG and BG than for those in CG (P < 0.05).

CONCLUSION:

The beneficial effects on infectious morbidity over 3 mo highlighted the potential of bLF supplementation for previously weaned infants; these findings may be applicable to other infants living in similar socioeconomic districts.

KEYWORDS:

Formula; Infant; Infectious morbidity; Lactoferrin; Supplementation

PMID:
26602290
DOI:
10.1016/j.nut.2015.08.010
[Indexed for MEDLINE]

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