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Biomed Opt Express. 2015 Oct 23;6(11):4529-38. doi: 10.1364/BOE.6.004529. eCollection 2015 Nov 1.

Screening neonatal jaundice based on the sclera color of the eye using digital photography.

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Department of Medical Physics & Biomedical Engineering, University College London, UK.
The Neonatal Care Unit, Elizabeth Garrett Anderson Wing, University College London Hospitals Trust, UK.
Department of Civil, Environmental & Geomatic Engineering, University College London, UK.


A new screening technique for neonatal jaundice is proposed exploiting the yellow discoloration in the sclera. It involves taking digital photographs of newborn infants' eyes (n = 110) and processing the pixel colour values of the sclera to predict the total serum bilirubin (TSB) levels. This technique has linear and rank correlation coefficients of 0.75 and 0.72 (both p<0.01) with the measured TSB. The mean difference ( ± SD) is 0.00 ± 41.60 µmol/l. The receiver operating characteristic curve shows that this technique can identify subjects with TSB above 205 µmol/l with sensitivity of 1.00 and specificity of 0.50, showing its potential as a screening device.


(300.6550) Spectroscopy, visible; (330.1710) Color, measurement

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