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Indian J Pharmacol. 2015 Sep-Oct;47(5):540-5. doi: 10.4103/0253-7613.165194.

Effects of aqueous extract of Hibiscus sabdariffa on the renin-angiotensin-aldosterone system of Nigerians with mild to moderate essential hypertension: A comparative study with lisinopril.

Author information

1
Department of Physiology, College of Medicine, University of Nigeria, Enugu Campus, Enugu, Enugu State, Nigeria.
2
Department of Medicine, Enugu State University of Science and Technology, Enugu, Enugu State, Nigeria.
3
Department of Physiology, School of Basic Medical Sciences, University of Benin, Benin City, Edo State, Nigeria.
4
Department of Ophthalmology, University of Nigeria Teaching Hospital, Enugu, Enugu State, Nigeria.

Abstract

OBJECTIVES:

The present study investigated the effects of aqueous extract of Hibiscus sabdariffa (HS) on the three basic components of renin-angiotensin-aldosterone system: Plasma renin, serum angiotensin-converting enzyme (ACE), and plasma aldosterone (PA) in mild to moderate essential hypertensive Nigerians and compared with that of lisinopril, an ACE inhibitor.

MATERIALS AND METHODS:

A double-blind controlled randomized clinical study was used. Seventy-eight newly diagnosed but untreated mild to moderate hypertensive subjects attending Medical Outpatients Clinic of Enugu State University Teaching Hospital, Enugu were recruited for the study. Those in Group A received placebo (150 mg/kg/day), Group B were given lisinopril (10 mg once daily) while those in Group C received aqueous extract of HS (150 mg/kg/day). After 4 weeks of treatment, the levels of plasma renin, serum ACE, and PA were determined.

RESULTS:

HS and lisinopril significantly (P < 0.001) reduced PA compared to placebo by 32.06% and 30.01%, respectively. Their effects on serum ACE and plasma renin activity (PRA) were not significant compared to placebo; they reduced ACE by 6.63% and 5.67% but increased plasma PRA by 2.77% and 5.36%, respectively.

CONCLUSION:

HS reduced serum ACE and PA in mild to moderate hypertensive Nigerians with equal efficacy as lisinopril. These actions are possibly due to the presence of anthocyanins in the extract.

KEYWORDS:

Aldosterone and essential hypertension; Hibiscus sabdariffa; angiotensin-converting enzyme; lisinopril; renin

PMID:
26600645
PMCID:
PMC4621677
DOI:
10.4103/0253-7613.165194
[Indexed for MEDLINE]
Free PMC Article

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