Send to

Choose Destination
Indian J Psychiatry. 2015 Jul-Sep;57(3):311-2. doi: 10.4103/0019-5545.166626.

Prolonged, longstanding, ultra-high-dose abuse of sildenafil.

Author information

Department of Psychiatry, JSS Medical College and Hospital, JSS University, Mysore, Karnataka, India.
Department of Psychopharmacology, National Institute of Mental Health and Neurosciences, Bengaluru, Karnataka, India.


We report a 40-year-old male who self-administered sildenafil for 10 years, in progressively increasing doses from 100 mg per occasion in the 1(st) year to 1300 mg per occasion in the 9(th)-10(th) years of (ab)use. The frequency of abuse was 2-3/week. The only adverse effect of concern that was reported was transient (up to about 12 h), self-limited blurring of vision in the last 2 years, especially in the last 2 months at the highest dose. The patient was otherwise normal. This report is unique because it describes what may be the highest dose of sildenafil reported in literature, abused across a protracted period of time. We discuss issues related to dose and safety of and tolerance to the drug.


Erectile dysfunction; phosphodiesterase type 5 inhibitors; sildenafil citrate

Supplemental Content

Full text links

Icon for Medknow Publications and Media Pvt Ltd Icon for PubMed Central
Loading ...
Support Center