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Ann Neurol. 2016 Mar;79(3):496-501. doi: 10.1002/ana.24566. Epub 2016 Feb 2.

Is in vivo amyloid distribution asymmetric in primary progressive aphasia?

Author information

1
Cognitive Neurology and Alzheimer's Disease Center, Northwestern University (NU) Feinberg School of Medicine, Chicago, IL.
2
The University of Arizona College of Medicine, Tucson, AZ.
3
NU Feinberg School of Medicine, Department of Preventive Medicine, Chicago, IL.
4
NU Feinberg School of Medicine, Department of Psychiatry and Behavioral Sciences, Chicago, IL.
5
Banner Alzheimer's Institute, Phoenix, AZ.
6
NU Feinberg School of Medicine, Department of Neurology, Chicago, IL.

Abstract

We aimed to determine whether (18) F-florbetapir amyloid positron emission tomography imaging shows a clinically concordant, left-hemisphere-dominant pattern of deposition in primary progressive aphasia (PPA). Elevated cortical amyloid (Aβ(+) ) was found in 19 of 32 PPA patients. Hemispheric laterality of amyloid burden was compared between Aβ(+) PPA and an Aβ(+) amnestic dementia groups (n = 22). The parietal region showed significantly greater left lateralized amyloid uptake in the PPA group than the amnestic group (p < 0.007), consistent with the left lateralized pattern of neurodegeneration in PPA. These results suggest that the cortical distribution of amyloid may have a greater clinical concordance than previously reported.

PMID:
26600088
PMCID:
PMC4789129
[Available on 2017-03-01]
DOI:
10.1002/ana.24566
[Indexed for MEDLINE]
Free PMC Article

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