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Food Funct. 2016 Apr;7(4):1775-87. doi: 10.1039/c5fo00886g.

Red wine polyphenols modulate fecal microbiota and reduce markers of the metabolic syndrome in obese patients.

Author information

1
Clinical Management Unit of Endocrinology and Nutrition of the Virgen de la Victoria Hospital, Biomedical Research Institute of Malaga (IBIMA), Malaga, Spain and Biomedical Research Networking Center for Pathophysiology of Obesity and Nutrition, CIBERobn, Madrid, Spain. fjtinahones@hotmail.com fernandocardonadiaz@gmail.com.
2
Clinical Management Unit of Endocrinology and Nutrition of the Virgen de la Victoria Hospital, Biomedical Research Institute of Malaga (IBIMA), Malaga, Spain.
3
Biomedical Research Networking Center for Pathophysiology of Obesity and Nutrition, CIBERobn, Madrid, Spain. fjtinahones@hotmail.com fernandocardonadiaz@gmail.com and Lipid and Atherosclerosis Unit, IMIBIC/Reina Sofia University Hospital/University of Cordoba, Spain.
4
Biomarkers and Nutrimetabolomic Lab. Department of Nutrition and Food Science, XaRTA, INSA, Faculty of Pharmacy, University of Barcelona, Barcelona, Spain and INGENIO-CONSOLIDER Program, Fun-c-food CSD2007-06, Barcelona, Spain.

Abstract

This study evaluated the possible prebiotic effect of a moderate intake of red wine polyphenols on the modulation of the gut microbiota composition and the improvement in the risk factors for the metabolic syndrome in obese patients. Ten metabolic syndrome patients and ten healthy subjects were included in a randomized, crossover, controlled intervention study. After a washout period, the subjects consumed red wine and de-alcoholized red wine over a 30 day period for each. The dominant bacterial composition did not differ significantly between the study groups after the two red wine intake periods. In the metabolic syndrome patients, red wine polyphenols significantly increased the number of fecal bifidobacteria and Lactobacillus (intestinal barrier protectors) and butyrate-producing bacteria (Faecalibacterium prausnitzii and Roseburia) at the expense of less desirable groups of bacteria such as LPS producers (Escherichia coli and Enterobacter cloacae). The changes in gut microbiota in these patients could be responsible for the improvement in the metabolic syndrome markers. Modulation of the gut microbiota by using red wine could be an effective strategy for managing metabolic diseases associated with obesity.

PMID:
26599039
DOI:
10.1039/c5fo00886g
[Indexed for MEDLINE]

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