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J Clin Oncol. 2016 Mar 1;34(7):669-76. doi: 10.1200/JCO.2015.61.6375. Epub 2015 Nov 23.

Randomized Trial Comparing Telephone Versus In-Person Weight Loss Counseling on Body Composition and Circulating Biomarkers in Women Treated for Breast Cancer: The Lifestyle, Exercise, and Nutrition (LEAN) Study.

Author information

1
Maura Harrigan, Brenda Cartmel, Erikka Loftfield, Tara Sanft, Anees B. Chagpar, Yang Zhou, Mary Playdon, Fangyong Li, and Melinda L. Irwin, Yale University; Brenda Cartmel, Tara Sanft, Anees B. Chagpar, Yang Zhou, Fangyong Li, and Melinda L. Irwin, Yale Cancer Center, New Haven, CT; and Erikka Loftfield and Mary Playdon, National Cancer Institute, Bethesda, MD.
2
Maura Harrigan, Brenda Cartmel, Erikka Loftfield, Tara Sanft, Anees B. Chagpar, Yang Zhou, Mary Playdon, Fangyong Li, and Melinda L. Irwin, Yale University; Brenda Cartmel, Tara Sanft, Anees B. Chagpar, Yang Zhou, Fangyong Li, and Melinda L. Irwin, Yale Cancer Center, New Haven, CT; and Erikka Loftfield and Mary Playdon, National Cancer Institute, Bethesda, MD. melinda.irwin@yale.edu.

Abstract

PURPOSE:

Obesity is associated with a higher risk of breast cancer mortality. The gold standard approach to weight loss is in-person counseling, but telephone counseling may be more feasible. We examined the effect of in-person versus telephone weight loss counseling versus usual care on 6-month changes in body composition, physical activity, diet, and serum biomarkers.

METHODS:

One hundred breast cancer survivors with a body mass index ≥ 25 kg/m(2) were randomly assigned to in-person counseling (n = 33), telephone counseling (n = 34), or usual care (UC) (n = 33). In-person and telephone counseling included 11 30-minute counseling sessions over 6 months. These focused on reducing caloric intake, increasing physical activity, and behavioral therapy. Body composition, physical activity, diet, and serum biomarkers were measured at baseline and 6 months.

RESULTS:

The mean age of participants was 59 ± 7.5 years old, with a mean BMI of 33.1 ± 6.6 kg/m(2), and the mean time from diagnosis was 2.9 ± 2.1 years. Fifty-one percent of the participants had stage I breast cancer. Average 6-month weight loss was 6.4%, 5.4%, and 2.0% for in-person, telephone, and UC groups, respectively (P = .004, P = .009, and P = .46 comparing in-person with UC, telephone with UC, and in-person with telephone, respectively). A significant 30% decrease in C-reactive protein levels was observed among women randomly assigned to the combined weight loss intervention groups compared with a 1% decrease among women randomly assigned to UC (P = .05).

CONCLUSION:

Both in-person and telephone counseling were effective weight loss strategies, with favorable effects on C-reactive protein levels. Our findings may help guide the incorporation of weight loss counseling into breast cancer treatment and care.

PMID:
26598750
PMCID:
PMC4872022
DOI:
10.1200/JCO.2015.61.6375
[Indexed for MEDLINE]
Free PMC Article

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