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J Cell Biol. 2015 Nov 23;211(4):745-55. doi: 10.1083/jcb.201509076.

The multifaceted roles of the HORMA domain in cellular signaling.

Author information

1
Ludwig Institute for Cancer Research, San Diego Branch, La Jolla, CA 92093.
2
Ludwig Institute for Cancer Research, San Diego Branch, La Jolla, CA 92093 Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA 92093 kcorbett@ucsd.edu.

Abstract

The HORMA domain is a multifunctional protein-protein interaction module found in diverse eukaryotic signaling pathways including the spindle assembly checkpoint, numerous DNA recombination/repair pathways, and the initiation of autophagy. In all of these pathways, HORMA domain proteins occupy key signaling junctures and function through the controlled assembly and disassembly of signaling complexes using a stereotypical "safety belt" peptide interaction mechanism. A recent explosion of structural and functional work has shed new light on these proteins, illustrating how strikingly similar structural mechanisms give rise to radically different functional outcomes in each family of HORMA domain proteins.

PMID:
26598612
PMCID:
PMC4657174
DOI:
10.1083/jcb.201509076
[Indexed for MEDLINE]
Free PMC Article

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