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Radiother Oncol. 2015 Dec;117(3):505-8. doi: 10.1016/j.radonc.2015.10.027. Epub 2015 Nov 17.

Scanning proton beam therapy reduces normal tissue exposure in pelvic radiotherapy for anal cancer.

Author information

1
Department of Radiation Oncology, Mayo Clinic, Phoenix/Scottsdale, United States. Electronic address: anand.aman@mayo.edu.
2
Department of Radiation Oncology, Mayo Clinic, Phoenix/Scottsdale, United States.
3
Department of Radiation Oncology, Mayo Clinic, Rochester, United States.
4
Cancer Center Statistics, Mayo Clinic, Rochester, United States.
5
Department of Radiation Oncology, Mayo Clinic, Jacksonville, United States.

Abstract

An inter-comparison planning study between photon beam therapy (IMRT) and scanning proton beam therapy (SPBT) for squamous cell carcinoma of the anus (SCCA) is presented. SPBT plans offer significant reduction (>50%, P=0.008) in doses to small bowel, and bone marrow thereby offering the potential to reduce bowel and hemotoxicities.

KEYWORDS:

Anal cancer; Bone marrow sparing; Spot scanning proton planning; Whole pelvis proton therapy

PMID:
26597231
DOI:
10.1016/j.radonc.2015.10.027
[Indexed for MEDLINE]

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