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Mol Immunol. 2015 Nov;68(1):45-8. doi: 10.1016/j.molimm.2015.06.006.

Complement factor H in its alternative identity as adrenomedullin-binding protein 1.

Author information

1
Department of Pharmacology, University of Oxford, Mansfield Road, Oxford OX1 3QT, UK; Department of Infection, Immunity and Inflammation, University of Leicester, University Rd, Leicester, LE1 9HN, UK. Electronic address: bob.sim@bioch.ox.ac.uk.
2
Department of Biochemistry, University of Oxford, South Parks Rd, Oxford OX1 3QU, UK; Centre for Infection, Immunity and Disease Mechanisms, Biosciences, Heinz Wolff Building, Brunel University, London UB8 3PH, UK.
3
Department of Infection, Immunity and Inflammation, University of Leicester, University Rd, Leicester, LE1 9HN, UK.
4
Centre for Infection, Immunity and Disease Mechanisms, Biosciences, Heinz Wolff Building, Brunel University, London UB8 3PH, UK.

Abstract

Complement factor H has been extensively studied since its discovery 50 years ago, and its role in the complement system is quite well established. It has another role, however, as a binding protein for the regulatory peptide adrenomedullin. Part of this role appears to be protection of adrenomedullin from proteolytic degradation. The binding interaction is unusual and merits further investigation. Adrenomedullin has potential therapeutic uses in diseases affecting the vasculature, and factor H has been administered with adrenomedullin in some animal models of disease.

KEYWORDS:

AMBP1; Adrenomedullin; Complement; Factor H; Haemorrhage; Protein–protein interaction; Sepsis

PMID:
26597206
DOI:
10.1016/j.molimm.2015.06.006
[Indexed for MEDLINE]

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