Format

Send to

Choose Destination
Mol Immunol. 2015 Nov;68(1):35-9. doi: 10.1016/j.molimm.2015.09.005.

IgA as therapeutic antibody.

Author information

1
Immunotherapy Laboratory, Laboratory for Translational Immunology, UMC Utrecht, The Netherlands. Electronic address: jleusen@umcutrecht.nl.

Abstract

This review is focused on the promises of IgA as a new therapeutic antibody. For more than 30 years IgG molecules have been used in the clinic in the fields of oncology, hematology, auto immune diseases and infections. However, IgA might be a good alternative, since it recruits different effector cells, i.e. polymorphonuclear cells or neutrophils, but can also activate monocytes and macrophages. The present knowledge, but also future direction for IgA- based drugs are discussed.

KEYWORDS:

Antibody therapy; IgA; Immunotherapy

PMID:
26597204
DOI:
10.1016/j.molimm.2015.09.005
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center