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Trends Parasitol. 2016 Feb;32(2):108-119. doi: 10.1016/j.pt.2015.09.007. Epub 2015 Nov 18.

Immunoglobulin M: Restrainer of Inflammation and Mediator of Immune Evasion by Plasmodium falciparum Malaria.

Author information

1
Liverpool School of Tropical Medicine, Pembroke Place, Liverpool, L3 5QA, UK. Electronic address: richard.pleass@lstmed.ac.uk.
2
Liverpool School of Tropical Medicine, Pembroke Place, Liverpool, L3 5QA, UK; Warwick Systems Biology Centre, Senate House, University of Warwick, Coventry, CV4 7AL, UK.
3
Centre for Medical Parasitology, Department of Immunology and Microbiology (ISIM), Faculty of Health and Medical Sciences, University of Copenhagen and Department of Infectious Diseases, Copenhagen University Hospital (Rigshospitalet), Copenhagen, Denmark.
4
Centre for Medical Parasitology, Department of Immunology and Microbiology (ISIM), Faculty of Health and Medical Sciences, University of Copenhagen and Department of Infectious Diseases, Copenhagen University Hospital (Rigshospitalet), Copenhagen, Denmark. Electronic address: lhviid@sund.ku.dk.

Abstract

Immunoglobulin M (IgM) is an ancient antibody class that is found in all vertebrates, with the exception of coelacanths, and is indispensable in both innate and adaptive immunity. The equally ancient human malaria parasite, Plasmodium falciparum, formed an intimate relationship with IgM with which it co-evolved. In this article, we discuss the association between IgM and human malaria parasites, building on several recent publications that implicate IgM as a crucial molecule that determines both host and parasite survival. Consequently, a better understanding of this association may lead to the development of improved intervention strategies.

KEYWORDS:

Fc receptors; IgM; Plasmodium falciparum; immune evasion; immunoglobulin M

PMID:
26597020
DOI:
10.1016/j.pt.2015.09.007
[Indexed for MEDLINE]

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