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Trends Neurosci. 2015 Dec;38(12):751-762. doi: 10.1016/j.tins.2015.10.005.

Homeotic Transformations of Neuronal Cell Identities.

Author information

1
Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA. Electronic address: Paola_Arlotta@harvard.edu.
2
Department of Biology and Department of Biochemistry and Molecular Biophysics, Howard Hughes Medical Institute, Columbia University, New York, NY, USA. Electronic address: or38@columbia.edu.

Abstract

Homeosis is classically defined as the transformation of one body part into something that resembles another body part. We propose here to broaden the concept of homeosis to the many neuronal cell identity transformations that have been uncovered over the past few years upon removal of specific regulatory factors in organisms from Caenorhabditis elegans to Drosophila, zebrafish, and mice. The concept of homeosis provides a framework for the evolution of cell type diversity in the brain.

PMID:
26596501
DOI:
10.1016/j.tins.2015.10.005
[Indexed for MEDLINE]

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