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Nat Immunol. 2016 Feb;17(2):150-8. doi: 10.1038/ni.3319. Epub 2015 Nov 30.

An innate antiviral pathway acting before interferons at epithelial surfaces.

Author information

1
Department of Biomedicine, University of Aarhus, Aarhus, Denmark.
2
Aarhus Research Center for Innate Immunology, University of Aarhus, Aarhus, Denmark.
3
Department of Cellular and Molecular Medicine, Centre for Glycomics, University of Copenhagen, Copenhagen, Denmark.
4
Department of Pediatrics and Microbiology, Albert Einstein College of Medicine, New York, USA.
5
Department of Regenerative Medicine, Military Institute of Hygiene and Epidemiology, Warsaw, Poland.
6
Department of Pediatrics, University of Virginia School of Medicine, Charlottesville, Virginia, USA.
7
Institute for Medical Immunology, Université Libre de Bruxelles, Gosselies, Belgium.
8
Department of Biostatistics, University of Aarhus, Aarhus, Denmark.
9
Department of Rheumatology and Inflammation Research, University of Gothenburg, Gothenburg, Sweden.
10
Institut für Klinische Chemie und Pathobiochemie, Klinikum rechts der Isar, Technische Universität München, Munich, Germany.
11
Department of Immunology and Microbiology, University of Copenhagen, Copenhagen, Denmark.

Abstract

Mucosal surfaces are exposed to environmental substances and represent a major portal of entry for microorganisms. The innate immune system is responsible for early defense against infections and it is believed that the interferons (IFNs) constitute the first line of defense against viruses. Here we identify an innate antiviral pathway that works at epithelial surfaces before the IFNs. The pathway is activated independently of known innate sensors of viral infections through a mechanism dependent on viral O-linked glycans, which induce CXCR3 chemokines and stimulate antiviral activity in a manner dependent on neutrophils. This study therefore identifies a previously unknown layer of antiviral defense that exerts its action on epithelial surfaces before the classical IFN response is operative.

Comment in

PMID:
26595890
DOI:
10.1038/ni.3319
[Indexed for MEDLINE]

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