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J Am Coll Nutr. 2016;35(3):217-23. doi: 10.1080/07315724.2014.971193. Epub 2015 Nov 23.

Ready-to-Eat Cereal Consumption with Total and Cause-Specific Mortality: Prospective Analysis of 367,442 Individuals.

Author information

1
a Department of Nutrition, Harvard School of Public Health , Boston , Massachusetts.
2
b NutraSource , Royal Oak , Michigan.
3
c Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School , Boston , Massachusetts.

Abstract

BACKGROUND:

Intakes of ready-to-eat cereal (RTEC) have been inversely associated with risk factors of chronic diseases such as cardiovascular disease (CVD), type 2 diabetes, and certain cancers; however, their relations with total and cause-specific mortality remain unclear.

OBJECTIVE:

To prospectively assess the associations of RTEC intakes with all causes and disease-specific mortality risk.

DESIGN:

The study included 367,442 participants from the prospective National Institutes of Health (NIH)-AARP Diet and Health Study. Intakes of RTEC were assessed at baseline.

RESULTS:

Over an average of 14 years of follow-up, 46,067 deaths were documented. Consumption of RTEC was significantly associated with reduced risk of mortality from all-cause mortality and death from CVD, diabetes, all cancer, and digestive cancer (all p for trend < 0.05). In multivariate models, compared to nonconsumers of RTEC, those in the highest intake of RTEC had a 15% lower risk of all-cause mortality and 10%-30% lower risk of disease-specific mortality. Within RTEC consumers, total fiber intakes were associated with reduced risk of mortality from all-cause mortality and deaths from CVD, all cancer, digestive cancer, and respiratory disease (all p for trend < 0.005).

CONCLUSIONS:

Consumption of RTEC was associated with reduced risk of all-cause mortality and mortality from specific diseases such as CVD, diabetes, and cancer. This association may be mediated via greater fiber intake.

TRIAL REGISTRATION:

ClinicalTrials.gov NCT00340015.

KEYWORDS:

CVD; fiber; mortality; ready-to-eat cereals

PMID:
26595440
PMCID:
PMC5325722
DOI:
10.1080/07315724.2014.971193
[Indexed for MEDLINE]
Free PMC Article

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