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J Med Food. 2015 Dec;18(12):1400-5. doi: 10.1089/jmf.2015.3577. Epub 2015 Nov 23.

Dead Nano-Sized Lactobacillus plantarum Inhibits Azoxymethane/Dextran Sulfate Sodium-Induced Colon Cancer in Balb/c Mice.

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1 Kimchi Research Institute, Pusan National University , Busan, Korea.
2 Department of Biotechnology, College of Life Science and Biotechnology, Korea University , Seoul, Korea.
3 Biogenics Korea Co., Ltd. , Seoul, Korea.


The chemopreventive effects of dead nano-sized Lactobacillus plantarum (nLp) on colon carcinogenesis, induced by dextran sulfate sodium and azoxymethane, were evaluated using Balb/c mice and compared with the effects of pure live L. plantarum (pLp). nLp is a dead shrunken form of L. plantarum derived from kimchi and has a particle size of 0.5-1.0 μm. Animals fed nLp showed less weight loss, longer colons, lower colon weight/length ratios, and fewer colonic tumors compared with pLp. In addition, the administration of nLp significantly reduced the expression of inflammatory markers, mediated the expression of cell cycle and apoptotic markers in colon tissues, and elevated fecal IgA levels more than pLp. Accordingly, the present study shows that the anticolorectal cancer activities of nLp are greater than those of pLp and suggests this is due to the suppression of inflammation, the induction of cell cycle arrest and apoptosis, and enhanced IgA secretion.


Balb/c mouse; anti-colorectal cancer; dead nano-sized Lactobacillus plantarum; fecal IgA

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