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Front Immunol. 2015 Nov 5;6:565. doi: 10.3389/fimmu.2015.00565. eCollection 2015.

The Ins and Outs of B Cells in Multiple Sclerosis.

Author information

1
Department of Neurology, University of Colorado Denver , Aurora, CO , USA.
2
Department of Neurology, University of Colorado Denver , Aurora, CO , USA ; Department of Ophthalmology, University of Colorado Denver , Aurora, CO , USA ; Program in Neuroscience, University of Colorado Denver , Aurora, CO , USA.

Abstract

B cells play a central role in multiple sclerosis (MS) pathology. B and plasma cells may contribute to disease activity through multiple mechanisms: antigen presentation, cytokine secretion, or antibody production. Molecular analyses of B cell populations in MS patients have revealed significant overlaps between peripheral lymphoid and clonally expanded central nervous system (CNS) B cell populations, indicating that B cell trafficking may play a critical role in driving MS exacerbations. In this review, we will assess our current knowledge of the mechanisms and pathways governing B cell migration into the CNS and examine evidence for and against a compartmentalized B cell response driving progressive MS pathology.

KEYWORDS:

B cells; blood–brain barrier; chemokines; lymphocyte trafficking; multiple sclerosis

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