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Nat Rev Microbiol. 2016 Jan;14(1):5-19. doi: 10.1038/nrmicro.2015.1. Epub 2015 Nov 23.

Targeting of host organelles by pathogenic bacteria: a sophisticated subversion strategy.

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Biologie des Bactéries Intracellulaires, Centre National de la Recherche Scientifique UMR 3525, Institut Pasteur, Biologie des 28 rue du Dr. Roux, 75724 Paris Cedex 15, France.


Many bacterial pathogens have evolved the ability to subvert and exploit host functions in order to enter and replicate in eukaryotic cells. For example, bacteria have developed specific mechanisms to target eukaryotic organelles such as the nucleus, the mitochondria, the endoplasmic reticulum and the Golgi apparatus. In this Review, we highlight the most recent advances in our understanding of the mechanisms that bacterial pathogens use to target these organelles. We also discuss how these strategies allow bacteria to manipulate host functions and to ultimately enable bacterial infection.

[Indexed for MEDLINE]

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