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Nutrients. 2015 Nov 18;7(11):9573-89. doi: 10.3390/nu7115486.

The Ratio of Dietary Branched-Chain Amino Acids is Associated with a Lower Prevalence of Obesity in Young Northern Chinese Adults: An Internet-Based Cross-Sectional Study.

Author information

1
Department of Nutrition and Food Hygiene, School of Public Health, Harbin Medical University, Harbin 150086, China. liyanchuan2013@foxmail.com.
2
Department of Nutrition and Food Hygiene, School of Public Health, Harbin Medical University, Harbin 150086, China. liying_helen@163.com.
3
Department of Nutrition and Food Hygiene, School of Public Health, Harbin Medical University, Harbin 150086, China. yanziliu2100@163.com.
4
Department of Nutrition and Food Hygiene, School of Public Health, Harbin Medical University, Harbin 150086, China. liushn0505@163.com.
5
Department of Nutrition and Food Hygiene, School of Public Health, Harbin Medical University, Harbin 150086, China. ztq0211@163.com.
6
Department of Nutrition and Food Hygiene, School of Public Health, Harbin Medical University, Harbin 150086, China. dushanshan1007@163.com.
7
College of Bioinformatics Science and Technology, Harbin Medical University, Harbin 150086, China. jiangyongshuai@126.com.
8
Department of Nutrition and Food Hygiene, School of Public Health, Harbin Medical University, Harbin 150086, China. changhao2002sun@gmail.com.
9
Department of Nutrition and Food Hygiene, School of Public Health, Harbin Medical University, Harbin 150086, China. fengrennan@163.com.

Abstract

This study aims to examine the association between the ratio of dietary branched chain amino acids (BCAA) and risk of obesity among young northern Chinese adults. A total of 948 randomly recruited participants were asked to finish our internet-based dietary questionnaire for the Chinese (IDQC). Associations between dietary BCAA ratio and prevalence of overweight/obesity and abdominal obesity were analyzed. Furthermore, 90 subjects were randomly selected to explore the possible mechanism. Dietary BCAA ratio in obese participants was significantly lower than non-obese participants. We found negative correlations between the ratio of dietary BCAA and body mass index (BMI) (r = -0.197, p < 0.001) or waist circumference (r = -0.187, p < 0.001). Compared with those in the first quartile, the multivariable-adjusted OR (95% CI) of the 3rd and 4th quartiles of dietary BCAA ratio for overweight/obesity were 0.508 (0.265-0.972) and 0.389 (0.193-0.783), respectively (all p < 0.05). After stratification by gender, the significance still existed in the 3rd and 4th quartile in males and the 4th quartile in females. For abdominal obesity, the multivariable-adjusted OR (95% CI) of the 3rd and 4th quartile of dietary BCAA ratio were 0.351 (0.145-0.845) and 0.376 (0.161-0.876), respectively (all p < 0.05). This significance was stronger in males. Further studies indicated that dietary BCAA ratio was inversely associated with 2-h postprandial glucose (2 h-PG) and status of inflammation. In conclusion, a higher ratio of dietary BCAA is inversely associated with prevalence of obesity, postprandial glucose and status of inflammation in young northern Chinese adults.

KEYWORDS:

2 h-PG; abdominal obesity; dietary BCAA; inflammation; overweight/obesity

PMID:
26593945
PMCID:
PMC4663614
DOI:
10.3390/nu7115486
[Indexed for MEDLINE]
Free PMC Article

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