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J Mol Cell Cardiol. 2016 Apr;93:149-55. doi: 10.1016/j.yjmcc.2015.11.015. Epub 2015 Nov 21.

Monocyte and macrophage contributions to cardiac remodeling.

Author information

1
Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, 185 Cambridge Street, Boston, MA 02114, USA.
2
Whitaker Cardiovascular Institute, Boston University School of Medicine, 715 Albany Street, Boston, MA 02118, USA.
3
Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, 185 Cambridge Street, Boston, MA 02114, USA. Electronic address: mnahrendorf@mgh.harvard.edu.

Abstract

The mammalian heart contains a population of resident macrophages that expands in response to myocardial infarction and hemodynamic stress. This expansion occurs likely through both local macrophage proliferation and monocyte recruitment. Given the role of macrophages in tissue remodeling, their contribution to adaptive processes in the heart is conceivable but currently poorly understood. In this review, we discuss monocyte and macrophage heterogeneity associated with cardiac stress, the cell's potential contribution to the pathogenesis of cardiac fibrosis, and describe different tools to study and characterize these innate immune cells. Finally, we highlight their potential role as therapeutic targets.

KEYWORDS:

Cardiac remodeling; Fibrosis; Hemodynamic stress; Macrophages; Monocytes; Myocardial infarction

PMID:
26593722
PMCID:
PMC4846552
DOI:
10.1016/j.yjmcc.2015.11.015
[Indexed for MEDLINE]
Free PMC Article

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