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J Am Med Dir Assoc. 2015 Dec;16(12):1034-41. doi: 10.1016/j.jamda.2015.09.007.

Prevalence of Mental Health Disorders Among Caregivers of Patients With Alzheimer Disease.

Author information

  • 1Yong Loo Lin School of Medicine, National University of Singapore, Singapore. Electronic address:
  • 2Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
  • 3Department of Psychological Medicine, National University Health System, Singapore.



The overall prevalence of mental health disorders among caregivers of patients with Alzheimer disease (AD) remains unclear. This meta-analysis aims to evaluate the prevalence of various mental health disorders among caregivers of patients with AD globally and to determine factors that predispose to development of the aforementioned, namely gender of caregiver, gender of patient, and caregiver-patient relationship.


A total of 17 studies were eligible for systematic review and meta-analysis. A meta-analysis of published work was performed using the random effect model. Data analysis was done with RevMan 5.3. A total of 10,825 caregivers were assessed.


The aggregate prevalence of depression among caregivers was 34.0%, anxiety at 43.6%, and use of psychotropic drugs at 27.2%. Meta-analysis revealed the odds of having of depression was 1.53 times higher in female caregivers (95% confidence interval [CI] 1.29-1.83; I(2) = 7%; Z = 4.78; P < .001), 1.86 times higher in caregivers to male care-recipients (95% CI 1.66-2.08; I(2) = 40%; Z = 10.86; P < .001), and 2.51 times higher in spousal caregivers (95% CI 1.68-3.76; I(2) = 55%; Z = 4.49; P < .001).


Caregivers of patients with AD have a higher prevalence of mental health disorders, particularly depression and anxiety, as compared with the general population and with their counterparts caring for patients with other illnesses. The higher prevalence is mainly observed in female caregivers, caregivers with male care-recipients, and caregivers who have a spousal relationship with care-recipients. Prevalence of anxiety was also notably higher in this cohort but more research needs to be done in this area.


Alzheimer disease; caregiver; mental health disorder; meta-analysis; prevalence; systemic review

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