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Clin Perinatol. 2015 Dec;42(4):697-718. doi: 10.1016/j.clp.2015.08.002. Epub 2015 Oct 1.

Postnatal Infections and Immunology Affecting Chronic Lung Disease of Prematurity.

Author information

1
Division of Neonatology, Department of Pediatrics, University of Rochester Medical Center, 601 Elmwood Avenue, Box 651, Rochester, NY 14642, USA; Department of Environmental Medicine, University of Rochester Medical Center, 601 Elmwood Avenue, Rochester, NY 14642, USA. Electronic address: gloria_pryhuber@urmc.rochester.edu.

Abstract

Premature infants suffer significant respiratory morbidity during infancy with long-term negative consequences on health, quality of life, and health care costs. Enhanced susceptibility to a variety of infections and inflammation play a large role in early and prolonged lung disease following premature birth, although the mechanisms of susceptibility and immune dysregulation are active areas of research. This article reviews aspects of host-pathogen interactions and immune responses that are altered by preterm birth and that impact chronic respiratory morbidity in these children.

KEYWORDS:

Bronchopulmonary dysplasia; Chronic lung disease of prematurity; Lymphocytes; Neonatal immunology; Neonatal infection; Prematurity; Preterm; Virus

PMID:
26593074
PMCID:
PMC4660246
DOI:
10.1016/j.clp.2015.08.002
[Indexed for MEDLINE]
Free PMC Article

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