Format

Send to

Choose Destination
See comment in PubMed Commons below
Biomed Pharmacother. 1989;43(1):11-7.

Dependence potential and abuse liability of nicotine replacement therapies.

Author information

1
Department of Psychiatry, University of Vermont College of Medicine, Burlington 05401.

Abstract

Some abstinent smokers develop withdrawal symptoms when they stop using nicotine gum or when placebo is substituted; thus, physical dependence on nicotine gum does occur. Some smokers also use nicotine gum beyond the recommended period; thus, behavioral dependence on the gum occurs. Many (7-41%) smokers misuse nicotine gum by smoking cigarettes and chewing the gum concurrently. Among smokers who stop using the gum, many (35-90%) do not stop gum use by the recommended 3 months, and a substantial percentage (13-38%) persist in gum use for 1 year. Among quitters, long-term use of nicotine gum appears to be greater than that of placebo gum. If rapidity of onset and frequency of use are determinants of dependence potential, then nasal sprays and aerosols but not nicotine patches should have dependence potential. There are no reports of misuse of the gum by non-smokers; thus, the gum appears to have little if any abuse liability.

PMID:
2659095
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Support Center