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Mol Cell. 2015 Nov 19;60(4):509-11. doi: 10.1016/j.molcel.2015.11.005.

Cancer Cells Hijack Gluconeogenic Enzymes to Fuel Cell Growth.

Author information

1
Department of Cancer Biology, Dana-Farber Cancer Institute and Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA.
2
Department of Cancer Biology, Dana-Farber Cancer Institute and Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA. Electronic address: pere_puigserver@dfci.harvard.edu.

Abstract

In this issue and the October 15th issue of Molecular Cell, studies by Montal et al. (2015) and Vincent et al. (2015) report that certain types of cancer cells utilize the gluconeogenic enzymes phosphoenolpyruvate carboxykinase (PEPCK) and phosphoenolpyruvate carboxykinase 2 (PCK2) to reprogram anabolic metabolism and support cell growth.

PMID:
26590709
DOI:
10.1016/j.molcel.2015.11.005
[Indexed for MEDLINE]
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