Format

Send to

Choose Destination
Environ Health. 2015 Nov 21;14:89. doi: 10.1186/s12940-015-0077-9.

Association between perfluoroalkyl acids and kidney function in a cross-sectional study of adolescents.

Author information

1
Department of Pediatrics, New York University School of Medicine, 227 East 30th St, Room 735, New York, NY, 10016, USA.
2
Department of Pediatrics, New York University School of Medicine, 227 East 30th St, Room 735, New York, NY, 10016, USA. leonardo.trasande@nyumc.org.
3
Department of Environmental Medicine, New York University School of Medicine, New York, NY, USA. leonardo.trasande@nyumc.org.
4
Department of Population Health, New York University School of Medicine, New York, NY, USA. leonardo.trasande@nyumc.org.
5
New York University Wagner School of Public Service, New York, NY, USA. leonardo.trasande@nyumc.org.
6
Department of Nutrition, Food Studies, and Public Health, New York University Steinhardt School of Culture, Education, and Human Development, New York, NY, USA. leonardo.trasande@nyumc.org.
7
New York University Global Institute of Public Health, New York, NY, USA. leonardo.trasande@nyumc.org.

Abstract

BACKGROUND:

Perfluoroalkyl acids are synthetic compounds widely used in industrial and commercial applications. Laboratory studies suggest that these persistent and bioaccumulative chemicals produce oxidant stress and damage glomerular endothelial cells, raising concern regarding the impact of these compounds on renal function.

METHODS:

We performed cross-sectional analyses of data 1960 participants aged 12-19 years of the 2003-2010 National Health and Nutrition Examination Surveys. PFAA exposure was assessed using levels of perfluorooctane sulfonic acid (PFOS), perfluorooctanoic acid (PFOA), perfluorononanoic acid, and perfluorohexane sulfonic acid. Primary study outcomes were estimated glomerular filtration rate (eGFR) and serum uric acid.

RESULTS:

While adjusting for demographics, cotinine, prehypertension, insulin resistance, body mass index, and hypercholesterolemia, adolescents in the highest PFOA and PFOS quartile had a lower eGFR, 6.84 mL/min/1.73 m(2) (95% CI: 2.19 to 11.48) and 9.69 mL/min/1.73 m(2) (95 % CI: -4.59 to 14.78), respectively, compared to the lowest quartile. Highest PFOA and PFOS quartiles were also associated with 0.21 mg/dL (95% CI: 0.056 to 0.37) and 0.19 mg/dL (95% CI: 0.032 to 0.34) increases in uric acid, respectively.

CONCLUSIONS:

PFAAs are associated with a reduction in kidney function and increased uric acid levels in otherwise healthy adolescents. Reverse causation and residual confounding could explain the results. Our study results confirm and amplify previous findings, though longitudinal studies examining prenatal and childhood biomarkers in relationship with robust measures of childhood renal function are needed.

PMID:
26590127
PMCID:
PMC4654837
DOI:
10.1186/s12940-015-0077-9
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for BioMed Central Icon for PubMed Central
Loading ...
Support Center