Format

Send to

Choose Destination
BMC Pediatr. 2015 Nov 20;15:192. doi: 10.1186/s12887-015-0506-5.

Etiologies of conjugated hyperbilirubinemia in infancy: a systematic review of 1692 subjects.

Author information

1
Childrens Hospital at Montefiore, New York, NY, USA.
2
Department of Pediatrics, Temple University School of Medicine, 3440 N. Broad St., Philadelphia, PA, 19104, USA.
3
Department of Pediatrics, Temple University School of Medicine, 3440 N. Broad St., Philadelphia, PA, 19104, USA. Aronoff@temple.edu.

Abstract

BACKGROUND:

The etiologies of conjugated hyperbilirubinemia in infancy are diverse.

OBJECTIVE:

Determine the prevalence rates of the specific etiologies of conjugated hyperbilirubinemia in infancy.

DATA SOURCES:

EMBASE and Pubmed were searched electronically and the bibliographies of selected studies were search manually. The search was conducted independently by two authors.

STUDY SELECTION:

(1) prospective or retrospective case series or cohort study with 10 or more subjects; (2) consecutive infants who presented with conjugated hyperbilirubinemia; (3) subjects underwent appropriate diagnostic work-up for conjugated hyperbilirubinemia; (4) no specific diagnoses were excluded in the studied cohort.

DATA EXTRACTION:

Patient number, age range, country of origin, and categorical and specific etiologies.

RESULTS:

From 237 studies identified, 17 studies encompassing 1692 infants were selected. Idiopathic neonatal hepatitis (INH) occurred in 26.0% of cases; the most common specific etiologies were extrahepatic biliary atresia (EHBA) (25.89%), infection (11.47%), TPN- associated cholestasis (6.44%), metabolic disease (4.37%), alpha-1 anti-trypsin deficiency (4.14%), and perinatal hypoxia/ischemia (3.66%). CMV was the most common infection identified (31.51%) and galactosemia (36.49%) was the most common metabolic disease identified.

LIMITATIONS:

Major limitations are: (1) inconsistencies in the diagnostic evaluations among the different studies and (2) variations among the sample populations.

CONCLUSIONS:

INH is the most common diagnosis for conjugated hyperbilirubinemia in infancy while EHBA and infection are the most commonly identified etiologies. The present review is intended to be a guide to the differential diagnosis and evaluation of the infant presenting with conjugated hyperbilirubinemia.

PMID:
26589959
PMCID:
PMC4654877
DOI:
10.1186/s12887-015-0506-5
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for BioMed Central Icon for PubMed Central
Loading ...
Support Center