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Curr Top Dev Biol. 2015;115:377-410. doi: 10.1016/bs.ctdb.2015.07.009. Epub 2015 Oct 6.

Transcription Factors in Craniofacial Development: From Receptor Signaling to Transcriptional and Epigenetic Regulation.

Author information

1
State Key Laboratory of Oral Diseases, Department of Orthodontics, West China Hospital of Stomatology, Sichuan University, Chengdu, China; Center for Craniofacial Molecular Biology, School of Dentistry, University of Southern California, Los Angeles, USA.
2
Center for Craniofacial Molecular Biology, School of Dentistry, University of Southern California, Los Angeles, USA; State Key Laboratory of Oral Diseases, Department of Prosthodontics, West China Hospital of Stomatology, Sichuan University, Chengdu, China.
3
Center for Craniofacial Molecular Biology, School of Dentistry, University of Southern California, Los Angeles, USA. Electronic address: xujian@usc.edu.

Abstract

Craniofacial morphogenesis is driven by spatial-temporal terrains of gene expression, which give rise to stereotypical pattern formation. Transcription factors are key cellular components that control these gene expressions. They are information hubs that integrate inputs from extracellular factors and environmental cues, direct epigenetic modifications, and define transcriptional status. These activities allow transcription factors to confer specificity and potency to transcription regulation during development.

KEYWORDS:

Gli; Homeobox; Runx; Smad; Sox; Transcription factor; bHLH; β-Catenin

PMID:
26589933
DOI:
10.1016/bs.ctdb.2015.07.009
[Indexed for MEDLINE]

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