Format

Send to

Choose Destination
Autoimmun Rev. 2016 Feb;15(2):198-201. doi: 10.1016/j.autrev.2015.11.006. Epub 2015 Nov 14.

Towards a better understanding of the clinical association of anti-DFS70 autoantibodies.

Author information

1
Inova Diagnostics, San Diego, CA, USA. Electronic address: mmahler@inovadx.com.
2
Division of Rheumatology, Department of Clinical Sciences and Community Health, University of Milan Istituto Auxologico Italiano, Milan, Italy.
3
Rheumatology Division, Department of Medicine, Escola Paulista de Medicina, Universidade Federal de São Paulo, Brazil.
4
Lupus Research Unit, The Rayne Institute, St Thomas Hospital, King's College London School of Medicine, London, UK.
5
Laboratory of Clinical Pathology, San Antonio Hospital, Tolmezzo, Italy.
6
Center for Health Disparities and Molecular Medicine, Department of Basic Sciences, Department of Medicine, Division of Rheumatology, Loma Linda University School of Medicine, Loma Linda, CA, USA.
7
Cumming School of Medicine, University of Calgary, Calgary, Canada.

Abstract

Anti-DFS70 antibodies and their clinical associations remain an immunological paradox. Unlike other antinuclear antibodies (ANA), especially when present at high titres, anti-DFS70 antibodies are not prevalent in ANA associated rheumatic diseases. Despite significant interest and progress in understanding the clinical association of anti-DFS70 antibodies, no specific clinical associations have been confirmed. In reality, several studies reporting clinical association of these antibodies (i.e. atopic dermatitis, thrombosis, autoimmune thyroiditis) have added confusion instead of bringing significant insight. In addition, several groups have consistently reported on the occurrence of anti-DFS70 antibodies in a relevant fraction of apparently healthy individuals. This review aims to analyse the current knowledge and to provide future guidance to analyse potential clinical associations of anti-DFS70 antibodies by summarizing and interpreting recent findings.

KEYWORDS:

Antinuclear antibodies; Autoantibodies; Autoimmune diseases; DFS; LEDGF

PMID:
26588998
DOI:
10.1016/j.autrev.2015.11.006
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center