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Chem Commun (Camb). 2016 Jan 18;52(5):942-5. doi: 10.1039/c5cc07792c.

Influence of a curcumin derivative on hIAPP aggregation in the absence and presence of lipid membranes.

Author information

1
Department of Chemistry, University of Michigan, Ann Arbor, MI 48109, USA. ramamoor@umich.edu.
2
Department of Chemistry, University of Michigan, Ann Arbor, MI 48109, USA. ramamoor@umich.edu and Department of Biophysics, Bose Institute, Kolkata 700 054, India.
3
Department of Organic Chemistry, School of Chemistry, Madurai Kamraj University, Madurai 21, India.
4
Department of Chemistry, University of Michigan, Ann Arbor, MI 48109, USA. ramamoor@umich.edu and Biophysics Program, University of Michigan, Ann Arbor, MI 48109, USA.

Abstract

The deposition of aggregates of human islet amyloid polypeptide (hIAPP) has been correlated with the death of β-cells in type II diabetes mellitus. The actual molecular mechanism of cell death remains largely unknown; however, it has been postulated that the process of aggregation from monomeric hIAPP is closely involved. A possible cause of cellular toxicity may be through the disruption of structural integrity of the cell membrane by IAPP. Herein, a water-soluble curcumin derivative, CurDAc, is used to investigate the mitigation of hIAPP aggregation in the absence and presence of lipid membrane.

PMID:
26587568
PMCID:
PMC4703533
DOI:
10.1039/c5cc07792c
[Indexed for MEDLINE]
Free PMC Article

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