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Iran J Public Health. 2015 Sep;44(9):1270-6.

Cardioprotective Effect of High Intensity Interval Training and Nitric Oxide Metabolites (NO2 (-), NO3 (-)).

Author information

1
Dept. of Physical Education and Sport Science, School of Education and Psychology, Shiraz University, Shiraz, Iran ; Sport Physiology Research Center, Baghiyatallah University of Medical Sciences, Tehran, Iran.
2
Dept. Exercise Physiology, Faculty of Physical Education and Sport Science, Tehran University, Tehran, Iran.
3
Dept. of Physiology, Arsanjan Branch, Islamic Azad University, Fars, Iran.
4
Sport Physiology Research Center, Baghiyatallah University of Medical Sciences, Tehran, Iran.

Abstract

BACKGROUND:

The aim of this study was to investigate the effects of High-Intensity Interval Training (HIIT) on nitric oxide metabolites (NO2(-), NO3(-)) and myocardial infarct size after Ischemia/Reperfusion (I/R) injury in healthy male rats.

METHODS:

A total of 44 Wistar rats were randomly divided into 4 groups including HIIT (n=8), HIIT + IR protocol (n=14), control (n=8), and control + IR (n=14). Each training session of HIIT consisted of 1 hour of exercise in three stages: 6-minute running at 50-60% VO2max for warm-up; 7 intervals of 7-minute running on treadmill with a slope of 5° to 20° (4 minutes with an intensity of 80-100% VO2max and 3 minutes at 50-60% VO2max); and 5-minute running at 50-60% VO2max for cool-down. The control group did not participate in any exercise program. Nitric Oxide (NO) and its metabolites were measured by using Griess reaction test.

RESULTS:

The results showed that eight weeks of exercise training exerted a significantly increasing effect on nitrite (8.55 μmol per liter, equivalent to 34.79%), nitrate (62.02 μmol per liter, equivalent to 149.48%), and NOx (66 μmol per liter, equivalent to 98.11%) in the HIIT group compared with the control group. The results showed myocardial infract size (IS) was significantly smaller (23.2%, P<0.001) in the exercise training group compared with the control group.

CONCLUSION:

Incremental changes in NO-NO3 (-), NO2 (-) axis are one of mechanisms through which HIIT program can protect the heart from I/R injury and decrease myocardial infarction.

KEYWORDS:

Cardioprotection; High-intensity interval training; NO; NO2−; NO3−; Preconditioning

PMID:
26587502
PMCID:
PMC4645785

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