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Oncoimmunology. 2015 Jun 1;4(12):e1052935. eCollection 2015 Dec.

ISG15: A double edged sword in cancer.

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Department of Biochemistry & Molecular Biology; LSU Health Sciences Center-School of Medicine ; New Orleans, LA USA.


Interferon-Stimulated Gene 15 (ISG15) transcript is aberrantly expressed in most human malignancies, suggesting that it has a protumor function. However, at the protein level ISG15 has both protumor and immunomodulatory antitumor functions. Therapeutic strategies to maximize the latter may benefit cancer patients overexpressing the ISG15 pathway.


ISG15; cancer; immune system; immunostimulatory cytokine; ubiquitin/26S proteasome

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