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Nat Commun. 2015 Nov 20;6:8919. doi: 10.1038/ncomms9919.

C. elegans maximum velocity correlates with healthspan and is maintained in worms with an insulin receptor mutation.

Author information

1
Center for Plant Aging Research, Institute for Basic Science, Daegu 42988, Republic of Korea.
2
Department of Molecular Biology, Lewis-Sigler Institute for Integrative Genomics, Princeton University, 148 Carl Icahn Laboratory, Washington Road, Princeton, New Jersey 08544, USA.
3
Department of Life Sciences and School of Interdisciplinary Bioscience and Bioengineering, Pohang University of Science and Technology, Pohang, Gyeongbuk 790-784, Republic of Korea.
4
Department of New Biology, DGIST, Daegu 42988, Republic of Korea.

Abstract

Ageing is marked by physical decline. Caenorhabditis elegans is a valuable model for identifying genetic regulatory mechanisms of ageing and longevity. Here we report a simple method to assess C. elegans' maximum physical ability based on the worms' maximum movement velocity. We show maximum velocity declines with age, correlates well with longevity, accurately reports movement ability and, if measured in mid-adulthood, is predictive of maximal lifespan. Contrary to recent findings, we observe that maximum velocity of worm with mutations in daf-2(e1370) insulin/IGF-1 signalling scales with lifespan. Because of increased odorant receptor expression, daf-2(e1370) mutants prefer food over exploration, causing previous on-food motility assays to underestimate movement ability and, thus, worm health. Finally, a disease-burden analysis of published data reveals that the daf-2(e1370) mutation improves quality of life, and therefore combines lifespan extension with various signs of an increased healthspan.

PMID:
26586186
PMCID:
PMC4656132
DOI:
10.1038/ncomms9919
[Indexed for MEDLINE]
Free PMC Article

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