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Cardiovasc Intervent Radiol. 2016 Jun;39(6):916-9. doi: 10.1007/s00270-015-1241-x. Epub 2015 Nov 19.

Indwelling Stent Embedded with Light-Emitting Diodes for Photodynamic Therapy of Malignant Biliary Obstruction.

Author information

1
Department of Imaging Sciences, University of Rochester Medical Center, 601 Elmwood Ave, Rochester, NY, 14642, USA.
2
The Joint Department of Medical Imaging, University Health Network, 700 University Ave, Toronto, ON, M5G 1X6, Canada.
3
Department of Imaging Sciences, University of Rochester Medical Center, 601 Elmwood Ave, Rochester, NY, 14642, USA. Ashwani_Sharma@URMC.Rochester.edu.

Abstract

PURPOSE:

We describe the design and preliminary characterization of a stent incorporating light-emitting diodes (LEDs) for photodynamic therapy (PDT) of malignant biliary obstruction.

METHODS:

A prototype was constructed with red (640 nm) LEDs embedded in a 14.5 French polyurethane tube. The device was evaluated for optical power and subjected to physical and electrical tests. PDT-induced reactive oxygen species were imaged in a gel phantom.

RESULTS:

The stent functioned at a 2.5-cm bend radius and illuminated for 6 months in saline. No stray currents were detected, and it was cool after 30 minutes of operation. Optical power of 5-15 mW is applicable to PDT. Imaging of a reactive oxygen indicator showed LED-stent activation of photosensitizer.

CONCLUSIONS:

The results motivate biological testing and design optimization.

KEYWORDS:

Bileduct; Biliary; Cancer; Catheter drainage; Interventional oncology

PMID:
26585991
DOI:
10.1007/s00270-015-1241-x
[Indexed for MEDLINE]

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