Format

Send to

Choose Destination
See comment in PubMed Commons below
Biochim Biophys Acta. 2016 Jun;1863(6 Pt B):1436-46. doi: 10.1016/j.bbamcr.2015.11.008. Epub 2015 Nov 14.

Beyond ion-conduction: Channel-dependent and -independent roles of TRP channels during development and tissue homeostasis.

Author information

  • 1Laboratory of Pediatric Oncology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Centre, Nijmegen, P.O.Box 9101, 6500 HB Nijmegen, The Netherlands. Electronic address: kirsten.vrenken@radboudumc.nl.
  • 2Division of Cell Biology, The Netherlands Cancer Institute NKI-AVL, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands. Electronic address: K.Jalink@nki.nl.
  • 3Laboratory of Pediatric Oncology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Centre, Nijmegen, P.O.Box 9101, 6500 HB Nijmegen, The Netherlands. Electronic address: frankn.vanleeuwen@radboudumc.nl.
  • 4Laboratory of Pediatric Oncology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Centre, Nijmegen, P.O.Box 9101, 6500 HB Nijmegen, The Netherlands. Electronic address: jeroen.middelbeek@radboudumc.nl.

Abstract

Transient receptor potential (TRP) channels comprise a family of cation channels implicated in a variety of cellular processes, including proliferation, cell migration and cell survival. As a consequence, members of this ion family play prominent roles during embryonic development, tissue maintenance and cancer progression. Although most TRP channels are non-selective, many cellular responses, mediated by TRP channels, appear to be calcium-dependent. In addition, there is mounting evidence for channel-independent roles for TRP channels. In this review, we will discuss how both these channel-dependent and -independent mechanisms affect cellular programs essential during embryonic development, and how perturbations in these pathways contribute to a variety of pathologies. This article is part of a Special Issue entitled: Calcium and Cell Fate. Guest Editors: Jacques Haiech, Claus Heizmann, Joachim Krebs, Thierry Capiod and Olivier Mignen.

KEYWORDS:

Calcium; Embryonic development; Epithelial-mesenchymal transition (EMT); TRP channels; Tissue homeostasis

PMID:
26585368
DOI:
10.1016/j.bbamcr.2015.11.008
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Support Center