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J Chromatogr A. 2015 Dec 11;1424:10-7. doi: 10.1016/j.chroma.2015.10.083. Epub 2015 Oct 30.

Tailoring and recycling of deep eutectic solvents as sustainable and efficient extraction media.

Author information

1
School of Pharmacy Sungkyunkwan University, 2066 Seoburo, Suwon 16419, Republic of Korea.
2
College of Pharmacy Seoul National University, 1 Gwanak-ro, Seoul 08826, Republic of Korea.
3
School of Pharmacy Sungkyunkwan University, 2066 Seoburo, Suwon 16419, Republic of Korea. Electronic address: jlee0610@skku.edu.

Abstract

The present study demonstrates that deep eutectic solvents (DESs) with the highest extractability can be designed by combining effective DES components from screening diverse DESs. The extraction of polar ginseng saponins from white ginseng was used as a way to demonstrate the tuneability as well as recyclability of DESs. A newly designed ternary DES (GPS-5) composed of glycerol, l-proline, and sucrose at 9:4:1 was used as a sustainable and efficient extraction medium. Based on the anti-tumor activity on HCT-116 cancer cells, it was confirmed that GPS-5 was merely an extraction solvent with no influence of the bioactivity of the ginsenosides extracted. Excellent recovery of the extracted saponins was easily achieved through solid-phase extraction (SPE). Recycling of the DES was accomplished by simple freeze-drying of the washed solutions from the SPE. The extraction efficiencies of the DESs recycled once, twice, and thrice were 92%, 85%, and 83% of that of the freshly synthesized solvent.

KEYWORDS:

Deep eutectic solvent; Ginsenoside; Green extraction; Solvent design; Solvent recycling

PMID:
26585205
DOI:
10.1016/j.chroma.2015.10.083
[Indexed for MEDLINE]

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