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Mol Cancer. 2015 Nov 19;14:197. doi: 10.1186/s12943-015-0471-5.

Identification of ANLN as ETV6 partner gene in recurrent t(7;12)(p15;p13): a possible role of deregulated ANLN expression in leukemogenesis.

Author information

  • 1Centro de Pesquisa Clinica, IIEP, Hopsital Albert Einstein, Av. Albert Einstein, 627/520, São Paulo, SP, Brazil. paulo.campregher@einstein.br.
  • 2Research Institute, Hospital Israelita Albert Einstein, São Paulo, Brazil. paulo.campregher@einstein.br.
  • 3Foundation Medicine, Cambridge, MT, USA. paulo.campregher@einstein.br.
  • 4Department of Hematology, University of Campinas/Hemocentro - Unicamp, Campinas, Brazil. paulo.campregher@einstein.br.
  • 5Research Institute, Hospital Israelita Albert Einstein, São Paulo, Brazil. welbert.pereira@einstein.br.
  • 6Research Institute, Hospital Israelita Albert Einstein, São Paulo, Brazil. lisboa.bianca@gmail.com.
  • 7Research Institute, Hospital Israelita Albert Einstein, São Paulo, Brazil. renato.puga@einstein.br.
  • 8Department of Hematology, Hospital Israelita Albert Einstein, São Paulo, Brazil. helman@einstein.br.
  • 9Research Institute, Hospital Israelita Albert Einstein, São Paulo, Brazil. marimiyagi@hotmail.com.
  • 10Research Institute, Hospital Israelita Albert Einstein, São Paulo, Brazil. evelyn.asc@hotmail.com.
  • 11Research Institute, Hospital Israelita Albert Einstein, São Paulo, Brazil. tarcila.datoguia@einstein.br.
  • 12Department of Hematology, Hospital Israelita Albert Einstein, São Paulo, Brazil. elvira.velloso@einstein.br.
  • 13Department of Hematology, Hospital Israelita Albert Einstein, São Paulo, Brazil. nsbacal@einstein.br.
  • 14Foundation Medicine, Cambridge, MT, USA. jross@foundationmedicine.com.
  • 15Department of Pathology and Laboratory Medicine, Albany Medical College, Albany, NY, USA. jross@foundationmedicine.com.
  • 16Foundation Medicine, Cambridge, MT, USA. sali@foundationmedicine.com.
  • 17Foundation Medicine, Cambridge, MT, USA. vmiller@foundationmedicine.com.
  • 18Department of Hematology, University of Campinas/Hemocentro - Unicamp, Campinas, Brazil. ferreira@unicamp.br.
  • 19Department of Hematology, Hospital Israelita Albert Einstein, São Paulo, Brazil. hamer@einstein.br.
  • 20Department of Hematology, Hospital Israelita Albert Einstein, São Paulo, Brazil. fabiopss@gmail.com.

Abstract

The ETV6 gene encodes an ETS family transcription factor that is involved in a myriad of chromosomal rearrangements found in hematological malignancies and other neoplasms. A recurrent ETV6 translocation, previously described in patients with acute myeloid leukemia (AML) (Genes Chromosomes Cancer 51:328-337,2012, Leuk Res 35:e212-214, 2011), whose partner has not been identified is t(7;12)(p15;p13). We herein report that the t(7;12)(p15;p13) fuses ETV6 to ANLN, a gene not previously implicated in the pathogenesis of hematological malignancies, and we demonstrate that this translocation leads to high expression of the fusion transcript in the myeloid and lymphoid lineages.

PMID:
26584717
PMCID:
PMC4653877
DOI:
10.1186/s12943-015-0471-5
[PubMed - indexed for MEDLINE]
Free PMC Article
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