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Mol Nutr Food Res. 2016 Mar;60(3):495-501. doi: 10.1002/mnfr.201500557. Epub 2016 Jan 7.

Flavonoids as dopaminergic neuromodulators.

Author information

1
Department of Biochemistry, Faculty of Medicine, University of Porto, Porto, Portugal.
2
Department of Pharmacology and Therapeutics, Faculty of Medicine, University of Porto, Porto, Portugal.
3
Unidad de Nutrición y Bromatología, Facultad de Farmacia, Universidad de Salamanca, Campus Miguel de Unamuno s/n, Salamanca, Espanha.
4
REQUIMTE/LAQV, Faculty of Sciences, University of Porto, Porto, Portugal.
5
Faculty of Nutrition and Food Sciences, University of Porto, Porto, Portugal.
6
CINTESIS - Center for Research in Health Technologies and Information Systems, Faculty of Medicine, University of Porto, Porto, Portugal.

Abstract

SCOPE:

The present study aimed to characterize and evaluate flavonoids effects on organic cation uptake in neuronal cells.

METHODS AND RESULTS:

Uptake experiments were conducted using radiolabeled methyl-4-phenylpyridinuim ([(3) H]-MPP(+) ), in human neuronal dopaminergic cells, SH-SY5Y. Catechin did not alter [(3) H]-MPP(+) uptake, however its metabolite 4'-methyl-catechin decreased it by almost 50%. Epicatechin and its methylated metabolites also decreased [(3) H]-MPP(+) uptake. Interestingly, the quercetin flavonol and its metabolite conjugated with glucuronic acid, as well as the flavanones naringenin and hesperitin, increased [(3) H]-MPP(+) uptake.

CONCLUSION:

These results showed that different classes of flavonoids, as well as its metabolites, differently influence neuronal organic cation uptake. Several xeno- and endobiotics, including neurotransmitters, are organic cations. Specific food recommendations may be beneficial in pathological conditions where levels of neurotransmitters, as dopamine, are either increased or decreased.

KEYWORDS:

Dopamine transporter; Dopaminergic cells; Flavonoids; Methyl-4-phenylpyridinuim; Organic cation transport

PMID:
26582321
DOI:
10.1002/mnfr.201500557
[Indexed for MEDLINE]

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