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J Int Neuropsychol Soc. 2015 Nov;21(10):841-50. doi: 10.1017/S1355617715000843.

Cardiorespiratory Fitness Attenuates the Influence of Amyloid on Cognition.

Author information

1
1Geriatric Research Education and Clinical Center,William S. Middleton Memorial Veterans Hospital,Madison,Wisconsin.
2
5Division of Cardiology,University of Wisconsin School of Medicine and Public Health,Madison,Wisconsin.
3
2Wisconsin Alzheimer's Disease Research Center,University of Wisconsin School of Medicine and Public Health,Madison,Wisconsin.
4
3Wisconsin Alzheimer's Institute,University of Wisconsin School of Medicine and Public Health,Madison,Wisconsin.
5
7Department of Biostatistics & Medical Informatics,University of Wisconsin School of Medicine and Public Health,Madison,Wisconsin.
6
10Clinical Neurochemistry Laboratory,Institute of Neuroscience and Physiology,The Sahlgrenska Academy at the University of Gothenburg,Mölndal,Sweden.

Abstract

The aim of this study was to examine cross-sectionally whether higher cardiorespiratory fitness (CRF) might favorably modify amyloid-β (Aβ)-related decrements in cognition in a cohort of late-middle-aged adults at risk for Alzheimer's disease (AD). Sixty-nine enrollees in the Wisconsin Registry for Alzheimer's Prevention participated in this study. They completed a comprehensive neuropsychological exam, underwent 11C Pittsburgh Compound B (PiB)-PET imaging, and performed a graded treadmill exercise test to volitional exhaustion. Peak oxygen consumption (VO2peak) during the exercise test was used as the index of CRF. Forty-five participants also underwent lumbar puncture for collection of cerebrospinal fluid (CSF) samples, from which Aβ42 was immunoassayed. Covariate-adjusted regression analyses were used to test whether the association between Aβ and cognition was modified by CRF. There were significant VO2peak*PiB-PET interactions for Immediate Memory (p=.041) and Verbal Learning & Memory (p=.025). There were also significant VO2peak*CSF Aβ42 interactions for Immediate Memory (p<.001) and Verbal Learning & Memory (p<.001). Specifically, in the context of high Aβ burden, that is, increased PiB-PET binding or reduced CSF Aβ42, individuals with higher CRF exhibited significantly better cognition compared with individuals with lower CRF. In a late-middle-aged, at-risk cohort, higher CRF is associated with a diminution of Aβ-related effects on cognition. These findings suggest that exercise might play an important role in the prevention of AD.

KEYWORDS:

Alzheimer’s disease; Amyloid; Cerebrospinal fluid; Cognition; Neuroimaging; Physical fitness

PMID:
26581795
PMCID:
PMC4716656
DOI:
10.1017/S1355617715000843
[Indexed for MEDLINE]
Free PMC Article

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