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Open Biol. 2015 Nov;5(11). pii: 150181. doi: 10.1098/rsob.150181.

There is no 'Conundrum' of InsP6.

Author information

1
Department of Pharmacology, University of Cambridge, Tennis Court Road, Cambridge CB2 1PD, UK rfi20@cam.ac.uk.
2
Department of Pharmacology, University of Cambridge, Tennis Court Road, Cambridge CB2 1PD, UK Department of Haematology, Cambridge University Hospitals NHS Trust, Hills Road, Cambridge CB2 0QQ, UK.
3
Medical Research Council Laboratory for Molecular Cell Biology, University College London, London, UK.
4
Medical Research Council Laboratory for Molecular Cell Biology, University College London, London, UK dmcbado@ucl.ac.uk.

Abstract

Indirect assays have claimed to quantify phytate (InsP6) levels in human biofluids, but these have been based on the initial assumption that InsP6 is there, an assumption that our more direct assays disprove. We have shown that InsP6 does not and cannot (because of the presence of an active InsP6 phosphatase in serum) exist in mammalian serum or urine. Therefore, any physiological effects of dietary InsP6 can only be due either to its actions in the gut as a polyvalent cation chelator, or to inositol generated by its dephosphorylation by gut microflora.

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PMID:
26581573
PMCID:
PMC4680572
DOI:
10.1098/rsob.150181
[Indexed for MEDLINE]
Free PMC Article

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