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Nat Struct Mol Biol. 2015 Nov;22(11):853-8. doi: 10.1038/nsmb.3078.

TERRA and the state of the telomere.

Author information

1
Research Group Genome Organization &Function, Deutsches Krebsforschungszentrum (DKFZ) and Bioquant Center, Heidelberg, Germany.
2
Institute of Molecular Biology (IMB), Mainz, Germany.

Abstract

Long noncoding telomeric repeat-containing RNA (TERRA) has been implicated in telomere maintenance in a telomerase-dependent and a telomerase-independent manner during replicative senescence and cancer. TERRA's proposed activities are diverse, thus making it difficult to pinpoint the critical roles that TERRA may have. We propose that TERRA orchestrates different activities at chromosome ends in a manner that depends on the state of the telomere.

PMID:
26581519
DOI:
10.1038/nsmb.3078
[Indexed for MEDLINE]

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