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J Contemp Dent Pract. 2015 Oct 1;16(10):840-4.

Primary Diffuse Large B-cell Lymphoma involving the Mandible.

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Board Resident, Department of Oral and Maxillofacial Surgery, King Fahad Medical City, Riyadh, Saudi Arabia, Phone: +966 56 444 4402, e-mail:
Department of Oral and Maxillofacial Surgery, Head and Neck Surgical Oncology, King Fahad Medical City, Riyadh Saudi Arabia.
Department of Adult Hematology and Blood Marrow Transplant, King Fahad Medical City, Riyadh, Saudi Arabia.
Department of Radiology, Unit of Neuroradiology, King Fahad Medical City, Riyadh, Saudi Arabia.
Department of Dental Health, College of Applied Medical Sciences, King Saud University, Riyadh, Saudi Arabia.


Lymphomas of the oral cavity are rare and typically present as intraosseous lesions that are most commonly diffuse large B-cell type. Diffuse large B-cell lymphoma (DLBCL) is an aggressive B-cell lymphoma histologically characterized by diffuse proliferation of large neoplastic B-lymphoid cells with a nuclear size equal to or exceeding normal histiocytic nuclei. A case of DLBCL of the mandible in an 18 years old male patient is presented. This report discusses this rare malignancy, including clinical presentation, histopathologic features, immunologic profile, treatment and prognosis. Though lymphoma of mandible is rare, it must be considered in differential diagnosis of swellings arising in the region.


B-cell lymphoma; Diffuse large B-cell lymphoma; Intraosseous lymphoma; Mandible; Non-Hodgkin’s lymphoma

[Indexed for MEDLINE]

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