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J Org Chem. 2015 Dec 18;80(24):12641-5. doi: 10.1021/acs.joc.5b02211. Epub 2015 Dec 2.

LDA-Promoted Synthesis of 3-Amino Furans by Selective Lithiation of Enaminones.

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1
Shanghai Key Laboratory of Green Chemistry and Chemical Processes, School of Chemistry and Molecular Engineering, East China Normal University , 500 Dongchuan Road, Shanghai 200241, China.

Abstract

An efficient cascade β-metalation/addition/cyclization reaction promoted by LDA is described in which 3-amino furans were constructed from enaminones and aldehydes. A broad range of substituents on the starting compounds was tolerated, and the polysubstituted furans were gained with moderate to excellent yields within 2 h.

PMID:
26579556
DOI:
10.1021/acs.joc.5b02211

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