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Nucleic Acids Res. 2016 Jan 4;44(D1):D126-32. doi: 10.1093/nar/gkv1203. Epub 2015 Nov 17.

ORegAnno 3.0: a community-driven resource for curated regulatory annotation.

Author information

1
McDonnell Genome Institute, Washington University School of Medicine, St. Louis, MO 63108, USA.
2
McDonnell Genome Institute, Washington University School of Medicine, St. Louis, MO 63108, USA Department of Genetics, Washington University School of Medicine, St. Louis, MO 63110, USA Siteman Cancer Center, Washington University School of Medicine, St. Louis, MO 63110, USA.
3
Canada's Michael Smith Genome Sciences Centre, BC Cancer Agency, Vancouver, BC V5Z 4S6, Canada.
4
Canada's Michael Smith Genome Sciences Centre, BC Cancer Agency, Vancouver, BC V5Z 4S6, Canada Department of Molecular Biology & Biochemistry, Simon Fraser University, Burnaby, BC V5A 1S6, Canada Department of Medical Genetics, University of British Columbia, Vancouver, BC V6T 1Z3, Canada.
5
Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA Department of Genetics, Stanford University School of Medicine, Stanford, CA 94305, USA smontgom@stanford.edu.
6
McDonnell Genome Institute, Washington University School of Medicine, St. Louis, MO 63108, USA Department of Genetics, Washington University School of Medicine, St. Louis, MO 63110, USA Siteman Cancer Center, Washington University School of Medicine, St. Louis, MO 63110, USA Department of Medicine, Division of Oncology, Washington University School of Medicine, St. Louis, MO 63110, USA ogriffit@genome.wustl.edu.

Abstract

The Open Regulatory Annotation database (ORegAnno) is a resource for curated regulatory annotation. It contains information about regulatory regions, transcription factor binding sites, RNA binding sites, regulatory variants, haplotypes, and other regulatory elements. ORegAnno differentiates itself from other regulatory resources by facilitating crowd-sourced interpretation and annotation of regulatory observations from the literature and highly curated resources. It contains a comprehensive annotation scheme that aims to describe both the elements and outcomes of regulatory events. Moreover, ORegAnno assembles these disparate data sources and annotations into a single, high quality catalogue of curated regulatory information. The current release is an update of the database previously featured in the NAR Database Issue, and now contains 1 948 307 records, across 18 species, with a combined coverage of 334 215 080 bp. Complete records, annotation, and other associated data are available for browsing and download at http://www.oreganno.org/.

PMID:
26578589
PMCID:
PMC4702855
DOI:
10.1093/nar/gkv1203
[Indexed for MEDLINE]
Free PMC Article

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