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Open Forum Infect Dis. 2015 Sep 19;2(4):ofv136. doi: 10.1093/ofid/ofv136. eCollection 2015 Dec.

West Nile Virus Central Nervous System Infection in Patients Treated With Rituximab: Implications for Diagnosis and Prognosis, With a Review of Literature.

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Infectious Disease Service, Department of Medicine.
Neuroradiology Service, Department of Radiology.
Departments of Pathology.
Immunology and Medicine , Memorial Sloan-Kettering Cancer Center , New York, New York.


The spectrum of West Nile virus (WNV) infection continues to be elucidated. Many cases of WNV are asymptomatic; however, in immunocompromised patients, symptoms are more likely to be severe. We describe fatal WNV central nervous system disease in lymphoma patients who received rituximab, blunting the inflammatory response and complicating diagnosis.


West Nile virus; immunocompromised host; lymphoma; molecular testing; rituximab

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