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Clin Exp Rheumatol. 2016 Mar-Apr;34(2 Suppl 96):S40-7. Epub 2015 Nov 17.

Fibromyalgia prevalence and related factors in a large registry of patients with systemic lupus erythematosus.

Author information

1
Department of Rheumatology, Hospitalet-Sant Joan Despí Moisès Broggi University General Hospital, Hospitalet Llobregat, Barcelona, Spain. vtorrente@hsjdbcn.org.
2
Rheumatology Department, Parc de Salut Mar-IMIM, Department of Medicine, Universitat Autònoma de Barcelona (UAB), Spain.
3
Rheumatology Department, Doctor Negrín University Hospital of Gran Canaria, Las Palmas de Gran Canaria, Spain.
4
Research Unit, Spanish Society of Rheumatology, Madrid, Spain.
5
Rheumatology Department, Gregorio Marañón University Hospital, Madrid, Spain.
6
Rheumatology Department, Doce de Octubre University Hospital, Madrid, Spain.
7
Rheumatology Department, Sierrallana Hospital, Torrelavega, Spain.
8
Rheumatology Department, Germans Trías i Pujol University Hospital, Badalona, Spain.
9
Rheumatology Unit, Clinica POVISA, Vigo, Spain.
10
Rheumatology Department, Navarra Hospital, Navarra, Pamplona, Spain.
11
Rheumatology Department, Príncipe de Asturias University Hospital, Madrid, Spain.
12
Rheumatology Department, Salamanca Clinic University Hospital, Salamanca, Spain.
13
Rheumatology Department, Complexo Hospitalario Universitario de Ourense, Ourense, Spain.
14
Rheumatology Department, León Hospital, León, Spain.
15
Rheumatology Department, Marqués de Valdecilla University Hospital, Santander, Spain.
16
Rheumatology Department, Puerta del Hierro-Majadahonda Hospital, Madrid, Spain.
17
Rheumatology Department, Basurto Hospital, Basurto, Spain.
18
Rheumatology Department, Hospital Insular of Gran Canaria, Las Palmas de Gran Canaria, Spain.
19
Rheumatology Department, Tenerife Clinic Hospital, Santa Cruz de Tenerife, Spain.
20
Rheumatology Department, Virgen Macarena Hospital, Sevilla, Spain.
21
Rheumatology Department, Miguel Servet University Hospital, Zaragoza, Spain.
22
Rheumatology Department, Virgen de la Arrixaca University Hospital, Murcia, Spain.
23
Rheumatology Department, La Paz University Hospital, Madrid, Spain.
24
Rheumatology Department, Complexo Hospitalario Universitario de Vigo, Instituto de Investigación Biomédica de Vigo (IBIV), Vigo, Spain.

Abstract

OBJECTIVES:

The objective of this study is to determine the prevalence of fibromyalgia (FM) in systemic lupus erythematosus (SLE) patients and to study its relationship to depression and other SLE-related factors.

METHODS:

A cross-sectional data analysis from the RELESSER-Transversal Spanish Registry, which includes SLE patients in a national multicentre retrospective charts review, was performed.

INCLUSION CRITERIA:

patients who fulfilled ≥4 ACR 1997 SLE criteria. Main variables were disease duration, depression, sociodemographics, comorbidities, SLE activity symptoms, serological findings, therapies and different disease status indices. Statistical analyses included a descriptive, associative and logistic regression analyses. A literature review was performed.

RESULTS:

3,591 SLE patients were included, 90.1% women, 34.6 years of age at diagnosis (SD 14.6 years) and 93.1% Caucasians. FM prevalence was 6.2%. SLE patients with disease duration >5 years showed more FM than those with duration <5 years: 6.9% vs. 4.0%, respectively (p<0.05). SLE-FM patients showed higher prevalence of depression compared to non-FM-SLE patients: 53.1% vs. 14.6%, respectively (p<0.001). After adjusting by risk factors, the OR (CI) of suffering depression in FM-SLE patients was 6.779 (4.770-9.636), p<0.001. The OR of having secondary Sjögren's 2.447 (1.662-3.604), p<0.001, photosensitivity 2.184 (1.431-3.334), p<0.001, and oral ulcers 1.436 (1.005-2.051), p=0.047.

CONCLUSIONS:

Prevalence of FM in Caucasian SLE patients was high compared to the general population, and was significantly higher in those in later stages of disease. SLE patients with depression showed a strong risk of developing FM. Photosensitivity, oral ulcers and secondary Sjögren's were the only SLE-related factors associated with FM.

PMID:
26575317
[Indexed for MEDLINE]

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