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EMBO J. 2016 Jan 4;35(1):46-61. doi: 10.15252/embj.201591807. Epub 2015 Nov 16.

Danger peptide receptor signaling in plants ensures basal immunity upon pathogen-induced depletion of BAK1.

Author information

1
Department of Plant-Microbe Interactions, Max Planck Institute for Plant Breeding Research, Cologne, Germany Graduate School of Agriculture, Kyoto University, Kyoto, Japan.
2
Department of Plant-Microbe Interactions, Max Planck Institute for Plant Breeding Research, Cologne, Germany.
3
Graduate School of Biological Sciences, Nara Institute of Science and Technology, Ikoma, Japan.
4
Department of Plant-Microbe Interactions, Max Planck Institute for Plant Breeding Research, Cologne, Germany Graduate School of Biological Sciences, Nara Institute of Science and Technology, Ikoma, Japan JST, PRESTO, Kawaguchi, Japan saijo@bs.naist.jp.

Abstract

Pathogens infect a host by suppressing defense responses induced upon recognition of microbe-associated molecular patterns (MAMPs). Despite this suppression, MAMP receptors mediate basal resistance to limit host susceptibility, via a process that is poorly understood. The Arabidopsis leucine-rich repeat (LRR) receptor kinase BAK1 associates and functions with different cell surface LRR receptors for a wide range of ligands, including MAMPs. We report that BAK1 depletion is linked to defense activation through the endogenous PROPEP peptides (Pep epitopes) and their LRR receptor kinases PEPR1/PEPR2, despite critical defects in MAMP signaling. In bak1-knockout plants, PEPR elicitation results in extensive cell death and the prioritization of salicylate-based defenses over jasmonate-based defenses, in addition to elevated proligand and receptor accumulation. BAK1 disruption stimulates the release of PROPEP3, produced in response to Pep application and during pathogen challenge, and renders PEPRs necessary for basal resistance. These findings are biologically relevant, since specific BAK1 depletion coincides with PEPR-dependent resistance to the fungal pathogen Colletotrichum higginsianum. Thus, the PEPR pathway ensures basal resistance when MAMP-triggered defenses are compromised by BAK1 depletion.

KEYWORDS:

Arabidopsis; BAK1; DAMP; PEPR; plant immunity

Comment in

PMID:
26574534
PMCID:
PMC4718002
DOI:
10.15252/embj.201591807
[Indexed for MEDLINE]
Free PMC Article

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