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Endocrine. 2016 Jun;52(3):516-26. doi: 10.1007/s12020-015-0798-0. Epub 2015 Nov 16.

Effects of liraglutide on left ventricular function in patients with non-ST-segment elevation myocardial infarction.

Author information

1
Department of Cardiology, PLA General Hospital at Beijing, Beijing, China.
2
International Medical Centre, PLA General Hospital at Beijing, Beijing, China.
3
Department of Cardiology, PLA General Hospital at Beijing, Beijing, China. 301chenyundai@sina.com.

Abstract

The influence of glucagon-like peptide-1 has been studied in several studies in patients with acute myocardial infarction, but not in patients with non-ST-segment elevation myocardial infarction (NSTEMI). We planned to evaluate the effects of liraglutide on left ventricular function in patients with NSTEMI. A total of 90 patients were randomized 1:1 to receive either liraglutide (0.6 mg for 2 days, 1.2 mg for 2 days, followed by 1.8 mg for 3 days) or placebo for 7 days. Eighty-three patients completed the trial. Transthoracic echocardiography was used to assess left ventricular function. At 3 months, the primary endpoint, the difference in the change in left ventricular ejection fraction between the two groups was +4.7 % (liraglutide vs. placebo 95 % CI +0.7 to +9.2 % P = 0.009) under intention-to-treat analysis. The difference in decrease in serum glycosylated hemoglobin levels was -0.2 % (liraglutide vs. placebo 95 % CI -0.1 to -0.3 %; P < 0.001). Inflammation and oxidative stress improved significantly in the liraglutide group compared to the placebo group. Liraglutide could improve left ventricular function in patients with NSTEMI, making it a potential adjuvant therapy for NSTEMI.

KEYWORDS:

Congestive heart failure; Glucagon-like peptide-1; Left ventricular ejection fraction; Metabolism; Non-ST-segment elevation myocardial infarction

PMID:
26573925
DOI:
10.1007/s12020-015-0798-0
[Indexed for MEDLINE]

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