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Reumatol Clin. 2016 Jul-Aug;12(4):201-5. doi: 10.1016/j.reuma.2015.09.003. Epub 2015 Nov 11.

Sjögren's syndrome-associated interstitial lung disease: A multicenter study.

[Article in English, Spanish]

Author information

1
Servicio de Reumatología, Hospital Sant Joan Despí Moisès Broggi, Spain. Electronic address: deliareinasanz@gmail.com.
2
Servicio de Reumatología, Hospital Sant Joan Despí Moisès Broggi, Spain.
3
Servicio de Reumatología, Hospital de Sant Pau, Spain.
4
Servicio de Reumatología, Hospital Parc Taulí, Spain.
5
Servicio de Reumatología, Hospital de Bellvitge, Spain.
6
Servicio de Reumatología, Hospital de Granollers, Spain.
7
Servicio de Neumología, Hospital Sant Joan Despí Moisès Broggi, Spain.
8
Clinical Epidemiology Department, Consorci Sanitari Integral, Spain.

Abstract

Primary Sjögren syndrome (PSS) is a chronic inflammatory autoimmune disease. Interstitial lung disease (ILD) can be an extraglandular complication.

OBJECTIVE:

To evaluate the clinical characteristics of patients diagnosed with PSS with ILD.

METHODS:

Multicentre cohort study with 25 patients diagnosed with PSS and ILD. Data of PSS, prognostic factors, pulmonary involvement variables, complementary tests that suggest a worse diagnosis and treatment given were collected. EULAR index was measured for Sjögren's syndrome.

RESULTS:

We identified 25 patients. In 15/25 the diagnosis of ILD was done before the diagnosis of PSS. The histopathological patterns found were: 12 NSIP, 5 UIP, 4 OP, 2 LIP. PFRs showed restrictive pattern. The majority of the patients received glucocorticoid therapy, antimalarial or immunosuppressive treatment.

CONCLUSIONS:

Patients affected with PSS must be screened to catch a precocious diagnosis of ILD. The majority of the patients were diagnosed of ILD before being diagnosed of PSS. Multicenter cohorts are increasingly demanded and a multidisciplinary management is needed.

KEYWORDS:

Enfermedad pulmonar intersticial; Interstitial lung disease; Sjögren syndrome; Síndrome de Sjögren

PMID:
26573882
DOI:
10.1016/j.reuma.2015.09.003
[Indexed for MEDLINE]
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